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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos; Embrapa Gado de Leite. |
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Data corrente: |
31/10/2023 |
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Data da última atualização: |
31/10/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FELIX, L. A.; GONZAGA, L. W. F.; SOARES, B. C. F.; SUÁREZ, G.; BRANDAO, H. de M.; FACCIOLI-MARTINS, P. Y.; FERRANTE, M. |
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Afiliação: |
UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDAD DE LA REPÚBLICA DE MONTEVIDEO; HUMBERTO DE MELLO BRANDAO, CNPGL; PATRICIA YOSHIDA FACCIOLI MARTINS, CNPC; UNIVERSIDADE FEDERAL DE LAVRAS. |
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Título: |
PK/PD integration for intramuscular dose determination of intramuscular sodium cloxacillin for infections caused by Staphylococcus spp in goat. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 75, n. 6, p. 1087-1096, 2023. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: This study aims to determine therapeutic protocols of intramuscular sodium cloxacillin (IM) in goats with potential antibacterial effects against Staphylococcus spp. We constructed a pharmacokinetic (PK) model of IM, followed by a pharmacokinetic/pharmacodynamic integration (PK/PD). Simulations of different therapeutic protocols were then performed, with the doses ranging from 30 to100 mg/kg every 8, 12, or 24 hours. We calculated the probability to target attainment (PTA) of reach protocol's therapeutic according to the minimum inhibitory concentration (MIC) range of 0.06 to 4 μg/mL. The PK/PD index (PDT) used was "time above the MIC for 40% of the time" (T>MIC ≥40%). Protocols with single administration per day were incapable of achieving PTA ≥ 90% for any of the estimated MICs. However, by decreasing the administration interval, the PTA was increased. Thus, from the dose of 50 mg/kg every 12 hours, a PTA≥ 90% for MICs ≤ 0.5 μg/mL was achieved, while the 30 mg/kg dose every 8 hours was able to achieve a PTA≥ 90% for MICs of 2 μg/mL. The results suggest using 30 mg/kg dose every 8 hours in clinical studies of agents with MICs ≤ 2μg/mL; Nevertheless, the practitioner should adjust the dose in severe patients.
Resumo: Objetivou-se determinar protocolos terapêuticos sistêmicos de cloxacilina sódica, via intramuscular, em caprinos, com potencial efeito antibacteriano contra Staphylococcus spp. Construiu-se um modelo farmacocinético (PK) de cloxacilina sódica em caprino; a partir deste, realizou-se a integração farmacocinéticas/farmacodinâmicas (PK/PD) e simulações de diferentes protocolos terapêuticos, variando de 30-100 mg/kg com administração a cada oito, 12 ou 24 horas. Foram calculadas as probabilidades de atingir o alvo (PTA) para cada protocolo, segundo uma distribuição de concentração inibitória mínima (CIM) de 0,06 a 4 μg/mL. O alvo PK/PD (PDT) utilizado foi de T>CIM ≥ 40%. Protocolos com uma administração por dia não foram capazes de atingir a PTA ≥ 90% para nenhuma das CIMs. A diminuição do intervalo aumentou os PTAs, assim, a partir da dose de 50 mg/kg a cada 12 horas, foi possível atingir PTA≥ 90% para CIMs ≤ 0,5 μg/mL, enquanto uma dose de 30 mg/kg a cada oito horas foi capaz de atingir PTA≥ 90% para uma CIM de 2 μg/mL. Os resultados sugerem que a dose de 30 mg/kg a cada oito horas pode ser utilizada em estudos clínicos de agentes com CIMs ≤ 2 μg/mL, porém é preciso ser avaliado como os parâmetros farmacocinéticos serão alterados em pacientes críticos. MenosAbstract: This study aims to determine therapeutic protocols of intramuscular sodium cloxacillin (IM) in goats with potential antibacterial effects against Staphylococcus spp. We constructed a pharmacokinetic (PK) model of IM, followed by a pharmacokinetic/pharmacodynamic integration (PK/PD). Simulations of different therapeutic protocols were then performed, with the doses ranging from 30 to100 mg/kg every 8, 12, or 24 hours. We calculated the probability to target attainment (PTA) of reach protocol's therapeutic according to the minimum inhibitory concentration (MIC) range of 0.06 to 4 μg/mL. The PK/PD index (PDT) used was "time above the MIC for 40% of the time" (T>MIC ≥40%). Protocols with single administration per day were incapable of achieving PTA ≥ 90% for any of the estimated MICs. However, by decreasing the administration interval, the PTA was increased. Thus, from the dose of 50 mg/kg every 12 hours, a PTA≥ 90% for MICs ≤ 0.5 μg/mL was achieved, while the 30 mg/kg dose every 8 hours was able to achieve a PTA≥ 90% for MICs of 2 μg/mL. The results suggest using 30 mg/kg dose every 8 hours in clinical studies of agents with MICs ≤ 2μg/mL; Nevertheless, the practitioner should adjust the dose in severe patients.
Resumo: Objetivou-se determinar protocolos terapêuticos sistêmicos de cloxacilina sódica, via intramuscular, em caprinos, com potencial efeito antibacteriano contra Staphylococcus spp. Construiu-se um mo... Mostrar Tudo |
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Palavras-Chave: |
Antibiotic therapy; Antibioticoterapia; Antimicrobial resistance; Antimicrobiano; Farmacometria; Modelo translacional; Resistência antimicrobiana; Sepse; Sepsis; Simulação de Monte Carlo. |
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Thesagro: |
Caprino; Farmacologia. |
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Thesaurus Nal: |
Dose response; Drugs; Goats; Pharmacology. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1157597/1/PK-PD-integration-for-intramuscular-dose-determination-of-intramuscular-sodium.pdf
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Marc: |
LEADER 03839naa a2200385 a 4500
001 2157597
005 2023-10-31
008 2023 bl uuuu u00u1 u #d
100 1 $aFELIX, L. A.
245 $aPK/PD integration for intramuscular dose determination of intramuscular sodium cloxacillin for infections caused by Staphylococcus spp in goat.$h[electronic resource]
260 $c2023
520 $aAbstract: This study aims to determine therapeutic protocols of intramuscular sodium cloxacillin (IM) in goats with potential antibacterial effects against Staphylococcus spp. We constructed a pharmacokinetic (PK) model of IM, followed by a pharmacokinetic/pharmacodynamic integration (PK/PD). Simulations of different therapeutic protocols were then performed, with the doses ranging from 30 to100 mg/kg every 8, 12, or 24 hours. We calculated the probability to target attainment (PTA) of reach protocol's therapeutic according to the minimum inhibitory concentration (MIC) range of 0.06 to 4 μg/mL. The PK/PD index (PDT) used was "time above the MIC for 40% of the time" (T>MIC ≥40%). Protocols with single administration per day were incapable of achieving PTA ≥ 90% for any of the estimated MICs. However, by decreasing the administration interval, the PTA was increased. Thus, from the dose of 50 mg/kg every 12 hours, a PTA≥ 90% for MICs ≤ 0.5 μg/mL was achieved, while the 30 mg/kg dose every 8 hours was able to achieve a PTA≥ 90% for MICs of 2 μg/mL. The results suggest using 30 mg/kg dose every 8 hours in clinical studies of agents with MICs ≤ 2μg/mL; Nevertheless, the practitioner should adjust the dose in severe patients. Resumo: Objetivou-se determinar protocolos terapêuticos sistêmicos de cloxacilina sódica, via intramuscular, em caprinos, com potencial efeito antibacteriano contra Staphylococcus spp. Construiu-se um modelo farmacocinético (PK) de cloxacilina sódica em caprino; a partir deste, realizou-se a integração farmacocinéticas/farmacodinâmicas (PK/PD) e simulações de diferentes protocolos terapêuticos, variando de 30-100 mg/kg com administração a cada oito, 12 ou 24 horas. Foram calculadas as probabilidades de atingir o alvo (PTA) para cada protocolo, segundo uma distribuição de concentração inibitória mínima (CIM) de 0,06 a 4 μg/mL. O alvo PK/PD (PDT) utilizado foi de T>CIM ≥ 40%. Protocolos com uma administração por dia não foram capazes de atingir a PTA ≥ 90% para nenhuma das CIMs. A diminuição do intervalo aumentou os PTAs, assim, a partir da dose de 50 mg/kg a cada 12 horas, foi possível atingir PTA≥ 90% para CIMs ≤ 0,5 μg/mL, enquanto uma dose de 30 mg/kg a cada oito horas foi capaz de atingir PTA≥ 90% para uma CIM de 2 μg/mL. Os resultados sugerem que a dose de 30 mg/kg a cada oito horas pode ser utilizada em estudos clínicos de agentes com CIMs ≤ 2 μg/mL, porém é preciso ser avaliado como os parâmetros farmacocinéticos serão alterados em pacientes críticos.
650 $aDose response
650 $aDrugs
650 $aGoats
650 $aPharmacology
650 $aCaprino
650 $aFarmacologia
653 $aAntibiotic therapy
653 $aAntibioticoterapia
653 $aAntimicrobial resistance
653 $aAntimicrobiano
653 $aFarmacometria
653 $aModelo translacional
653 $aResistência antimicrobiana
653 $aSepse
653 $aSepsis
653 $aSimulação de Monte Carlo
700 1 $aGONZAGA, L. W. F.
700 1 $aSOARES, B. C. F.
700 1 $aSUÁREZ, G.
700 1 $aBRANDAO, H. de M.
700 1 $aFACCIOLI-MARTINS, P. Y.
700 1 $aFERRANTE, M.
773 $tArquivo Brasileiro de Medicina Veterinária e Zootecnia$gv. 75, n. 6, p. 1087-1096, 2023.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Registro |
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Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
21/06/2011 |
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Data da última atualização: |
23/02/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
CORRÊA, R. S.; BELLOTE, A. F. J. |
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Afiliação: |
Robson Schaff Corrêa, Universidade Federal de Santa Maria; ANTONIO FRANCISCO JURADO BELLOTE, CNPF. |
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Título: |
Soil attributes and biomass yield from Pinus caribaea var. hondurensis. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Cerne, Lavras, v. 17, n. 2, p. 181-187, abr./jun. 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Biomass yield from Pinus caribaea var. hondurensis is conditional on soil attributes. With the silvicultural practice currently being used in Brazil, Pinus stands might produce lower yields due to nutrient shift from harvest and due to changes in the edaphic environment from mechanization. Therefore, this study aims to evaluate chemical and physical soil attributes and determine which are correlated with higher biomass yields. Four commercial stands were selected, with differing growth patterns, each having four trees selected from the dominant layer, in addition to soil samples for chemical and physical analyses. Soil attributes and biomass yield data were submitted to analysis of variance (ANOVA), means were compared by the Tukey test, and the Pearson correlation coeffi cient was determined. Chemical attributes directly or indirectly associated with the sum of bases and physical attributes associated with water availability were found to be related to biomass yield. |
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Palavras-Chave: |
Fertility; Growth. |
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Thesagro: |
Crescimento; Fertilidade; Física do Solo; Nutrição; Pinus Caribaea; Silvicultura. |
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Thesaurus NAL: |
nutrition; silviculture; soil physics. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/36704/1/revista-cerne.pdf
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Marc: |
LEADER 01675naa a2200265 a 4500
001 1894589
005 2015-02-23
008 2011 bl uuuu u00u1 u #d
100 1 $aCORRÊA, R. S.
245 $aSoil attributes and biomass yield from Pinus caribaea var. hondurensis.
260 $c2011
520 $aBiomass yield from Pinus caribaea var. hondurensis is conditional on soil attributes. With the silvicultural practice currently being used in Brazil, Pinus stands might produce lower yields due to nutrient shift from harvest and due to changes in the edaphic environment from mechanization. Therefore, this study aims to evaluate chemical and physical soil attributes and determine which are correlated with higher biomass yields. Four commercial stands were selected, with differing growth patterns, each having four trees selected from the dominant layer, in addition to soil samples for chemical and physical analyses. Soil attributes and biomass yield data were submitted to analysis of variance (ANOVA), means were compared by the Tukey test, and the Pearson correlation coeffi cient was determined. Chemical attributes directly or indirectly associated with the sum of bases and physical attributes associated with water availability were found to be related to biomass yield.
650 $anutrition
650 $asilviculture
650 $asoil physics
650 $aCrescimento
650 $aFertilidade
650 $aFísica do Solo
650 $aNutrição
650 $aPinus Caribaea
650 $aSilvicultura
653 $aFertility
653 $aGrowth
700 1 $aBELLOTE, A. F. J.
773 $tCerne, Lavras$gv. 17, n. 2, p. 181-187, abr./jun. 2011.
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Registro original: |
Embrapa Florestas (CNPF) |
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